2021 Lexus IS 350 fuel economy
The EPA lists 2 versions of the 2021 Lexus IS 350. Combined fuel economy ranges from 22 to 23 MPG; the most efficient version is rated 20 city / 28 highway.
At a glance
- Combined
- 22 to 23 MPG depending on version
- City and highway
- 20 and 28 most efficient version
- Yearly fuel cost
- $3,550 EPA estimate, most efficient version
Source: U.S. EPA fueleconomy.gov
Every version the EPA tested
| Version | Engine | Drive | City | Highway | Combined | Yearly fuel cost |
|---|---|---|---|---|---|---|
| IS 350 Automatic (S8) | 6-cyl 3.5L | Rear-Wheel Drive | 20 | 28 | 23 MPG | $3,550 |
| IS 350 AWD Automatic (S6) | 6-cyl 3.5L | All-Wheel Drive | 19 | 26 | 22 MPG | $3,750 |
At EPA assumptions, the most efficient version costs about $3,550 per year in fuel, versus $3,750 for the least efficient.