2022 Mercedes-Benz E 450 4MATIC All-Terrain
The EPA rates the 2022 Mercedes-Benz E 450 4MATIC All-Terrain at 24 MPG combined (21 city / 28 highway).
At a glance
- Fuel economy
- 24 MPG combined
Sources: NHTSA complaints, recalls and 5-Star ratings; U.S. EPA
Fuel economy
The EPA rates the 2022 Mercedes-Benz E 450 4MATIC All-Terrain at 24 MPG combined (21 city / 28 highway).