2021 Mercedes-Benz E 450 4MATIC Coupe
The EPA rates the 2021 Mercedes-Benz E 450 4MATIC Coupe at 25 MPG combined (23 city / 30 highway).
At a glance
- Fuel economy
- 25 MPG combined
Sources: NHTSA complaints, recalls and 5-Star ratings; U.S. EPA
Fuel economy
The EPA rates the 2021 Mercedes-Benz E 450 4MATIC Coupe at 25 MPG combined (23 city / 30 highway).