2021 Mercedes-Benz E 450 fuel economy
The EPA lists 2 versions of the 2021 Mercedes-Benz E 450. Combined fuel economy ranges from 25 to 26 MPG; the most efficient version is rated 23 city / 31 highway.
At a glance
- Combined
- 25 to 26 MPG depending on version
- City and highway
- 23 and 31 most efficient version
- Yearly fuel cost
- $3,150 EPA estimate, most efficient version
Source: U.S. EPA fueleconomy.gov
Every version the EPA tested
| Version | Engine | Drive | City | Highway | Combined | Yearly fuel cost |
|---|---|---|---|---|---|---|
| E450 Coupe Automatic 9-spd | 6-cyl 3.0L Hybrid | Rear-Wheel Drive | 23 | 31 | 26 MPG | $3,150 |
| E450 Convertible Automatic 9-spd | 6-cyl 3.0L Hybrid | Rear-Wheel Drive | 23 | 30 | 25 MPG | $3,300 |
At EPA assumptions, the most efficient version costs about $3,150 per year in fuel, versus $3,300 for the least efficient.