2021 Mercedes-Benz GLS 450 4MATIC
The EPA rates the 2021 Mercedes-Benz GLS 450 4MATIC at 21 MPG combined (20 city / 24 highway).
At a glance
- Fuel economy
- 21 MPG combined
Sources: NHTSA complaints, recalls and 5-Star ratings; U.S. EPA
Fuel economy
The EPA rates the 2021 Mercedes-Benz GLS 450 4MATIC at 21 MPG combined (20 city / 24 highway).