2022 Mercedes-Benz S 500 4MATIC fuel economy
The EPA rates the 2022 Mercedes-Benz S 500 4MATIC at 24 MPG combined (21 city / 30 highway).
At a glance
- Combined
- 24 MPG
- City and highway
- 21 and 30 most efficient version
- Yearly fuel cost
- $3,400 EPA estimate, most efficient version
Source: U.S. EPA fueleconomy.gov
Every version the EPA tested
| Version | Engine | Drive | City | Highway | Combined | Yearly fuel cost |
|---|---|---|---|---|---|---|
| S500 4matic Automatic 9-spd | 6-cyl 3.0L Hybrid | All-Wheel Drive | 21 | 30 | 24 MPG | $3,400 |
At EPA assumptions, the most efficient version costs about $3,400 per year in fuel.