2026 Mercedes-Benz S 500 4MATIC
The EPA rates the 2026 Mercedes-Benz S 500 4MATIC at 23 MPG combined (20 city / 29 highway).
At a glance
- Fuel economy
- 23 MPG combined
Sources: NHTSA complaints, recalls and 5-Star ratings; U.S. EPA
Fuel economy
The EPA rates the 2026 Mercedes-Benz S 500 4MATIC at 23 MPG combined (20 city / 29 highway).