2025 Mercedes-Benz S 580 4MATIC fuel economy
The EPA rates the 2025 Mercedes-Benz S 580 4MATIC at 20 MPG combined (17 city / 25 highway).
At a glance
- Combined
- 20 MPG
- City and highway
- 17 and 25 most efficient version
- Yearly fuel cost
- $4,100 EPA estimate, most efficient version
Source: U.S. EPA fueleconomy.gov
Every version the EPA tested
| Version | Engine | Drive | City | Highway | Combined | Yearly fuel cost |
|---|---|---|---|---|---|---|
| S580 4matic Automatic 9-spd | 8-cyl 4.0L Hybrid | All-Wheel Drive | 17 | 25 | 20 MPG | $4,100 |
At EPA assumptions, the most efficient version costs about $4,100 per year in fuel.