2026 Mercedes-Benz S 580 4MATIC
The EPA rates the 2026 Mercedes-Benz S 580 4MATIC at 20 MPG combined (17 city / 27 highway).
At a glance
- Fuel economy
- 20 MPG combined
Sources: NHTSA complaints, recalls and 5-Star ratings; U.S. EPA
Fuel economy
The EPA rates the 2026 Mercedes-Benz S 580 4MATIC at 20 MPG combined (17 city / 27 highway).