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2014 Mercedes-Benz E 350 4MATIC fuel economy

The EPA lists 6 versions of the 2014 Mercedes-Benz E 350 4MATIC. Combined fuel economy ranges from 22 to 23 MPG; the most efficient version is rated 20 city / 28 highway.

At a glance

Combined
22 to 23 MPG depending on version
City and highway
20 and 28 most efficient version
Yearly fuel cost
$3,550 EPA estimate, most efficient version

Source: U.S. EPA fueleconomy.gov

Every version the EPA tested

VersionEngineDriveCityHighwayCombinedYearly fuel cost
E350 4matic
Automatic 7-spd
6-cyl 3.5L FFV 4-Wheel Drive 202823 MPG $3,550
E350 4matic
Automatic 7-spd
6-cyl 3.5L 4-Wheel Drive 202723 MPG $3,550
E350 4matic Coupe
Automatic 7-spd
6-cyl 3.5L 4-Wheel Drive 202823 MPG $3,550
E350 4matic Coupe
Automatic 7-spd
6-cyl 3.5L FFV 4-Wheel Drive 202823 MPG $3,550
E350 4matic
Automatic 7-spd
6-cyl 3.5L 4-Wheel Drive 202722 MPG $3,750
E350 4matic (wagon)
Automatic 7-spd
6-cyl 3.5L 4-Wheel Drive 202622 MPG $3,750
EPA estimates under standard test conditions. Your mileage will vary with driving style, load and weather.

At EPA assumptions, the most efficient version costs about $3,550 per year in fuel, versus $3,750 for the least efficient.

Work out what this car would cost you in fuel each year

Fuel economy in other model years