2022 Mercedes-Benz E 450 4MATIC
The EPA lists 2 versions of the 2022 Mercedes-Benz E 450 4MATIC. Combined fuel economy ranges from 24 to 25 MPG; the most efficient version is rated 23 city / 30 highway.
At a glance
- Fuel economy
- 24 to 25 MPG combined
Sources: NHTSA complaints, recalls and 5-Star ratings; U.S. EPA
Fuel economy
The EPA lists 2 versions of the 2022 Mercedes-Benz E 450 4MATIC. Combined fuel economy ranges from 24 to 25 MPG; the most efficient version is rated 23 city / 30 highway.