2025 Mercedes-Benz E 450 4MATIC
The EPA rates the 2025 Mercedes-Benz E 450 4MATIC at 25 MPG combined (22 city / 31 highway).
At a glance
Sources: NHTSA complaints, recalls and 5-Star ratings; U.S. EPA
Recalls
The 2025 Mercedes-Benz E 450 4MATIC is affected by 2 safety recall campaigns in NHTSA's records.
All 2 recall campaigns for the 2025 Mercedes-Benz E 450 4MATIC
Fuel economy
The EPA rates the 2025 Mercedes-Benz E 450 4MATIC at 25 MPG combined (22 city / 31 highway).