Vehicle Data Hub

2006 Mercedes-Benz E350 engine problems

72 complaints about engine have been filed for the 2006 Mercedes-Benz E350, which is 15% of all its NHTSA complaints. It is the 2nd most reported problem area for this model year.

At a glance

Complaints
72 15% of this year's complaints
Typical mileage
92,000 miles 55 complaints with mileage
Crashes and fires
4 and 4
Injuries and deaths
10 and 1

Source: NHTSA owner complaints

When engine problems show up

Engine complaints by mileage, 2006 Mercedes-Benz E350 Complaints by odometer reading in 20,000-mile steps. The median is about 92,000 miles. 0k to 20k miles: 0 complaints 20k to 40k miles: 2 complaints 40k to 60k miles: 8 complaints 60k to 80k miles: 11 complaints 80k to 100k miles: 11 complaints 100k to 120k miles: 9 complaints 120k to 140k miles: 5 complaints 140k to 160k miles: 6 complaints 160k to 180k miles: 1 complaints 180k to 200k miles: 1 complaints 200k+ miles: 1 complaints 040k80k120k160k200k miles Typical: 92,000 miles
Based on 55 complaints that include mileage. 18% were reported before 60,000 miles. The amber marker shows the median: half of these complaints happened before that mileage.
View the numbers
MileageComplaints
0k to 20k miles0
20k to 40k miles2
40k to 60k miles8
60k to 80k miles11
80k to 100k miles11
100k to 120k miles9
120k to 140k miles5
140k to 160k miles6
160k to 180k miles1
180k to 200k miles1
200k+ miles1

What the data shows

Of the 55 engine complaints that report mileage, the median is about 92,000 miles, and 18% were reported before 60,000 miles.

These complaints mention 4 crashes, 4 fires, 10 injuries, 1 death.

What owners wrote

I am reporting a very serious, disturbing, shocking and tragic accident on 9/12/2015 on randall road in elgin, il USA at 2:35 pm just after big timber road signal.my southbound 2006 mercedes benz e350 car was hit by the high speed out of control northbound 2014 toyota corolla, which had crossed/swerved the center line and resulted in a head on collision/crash.....updated 10-27-15

Reported at 117,000 miles, September 2015 CrashInjuryDeath

Fuel pump leaking fumes (and fuel?). While parked and preparing to come home the fuel pump failed and the car refused to start. It will not be repaired unless it is under the extended warranty. I am trying to learn if it will be covered under a extended warranty.

Reported at 155,600 miles, May 2018

Other problems reported for the 2006 Mercedes-Benz E350

Engine problems in other years

Engine problems across all Mercedes-Benz models