Vehicle Data Hub

2006 Mercedes-Benz E350 problems

Owners have filed 485 complaints with NHTSA about the 2006 Mercedes-Benz E350. Fuel system is the most reported problem area, at 46% of complaints. After that come engine (15%) and brakes (11%).

At a glance

Complaints
485 filed with NHTSA
Most reported
Fuel system 46% of complaints
Crashes and fires
20 and 13
Injuries and deaths
36 and 3
Typical mileage
91,000 miles 403 complaints with mileage

Source: NHTSA owner complaints

Where the complaints are

Share of this model year's complaints by the part of the car involved. One complaint can name more than one part, so the shares can add up to more than 100%.

When problems show up

Complaints by mileage, 2006 Mercedes-Benz E350 Complaints by odometer reading in 20,000-mile steps. The median is about 91,000 miles. 0k to 20k miles: 17 complaints 20k to 40k miles: 25 complaints 40k to 60k miles: 49 complaints 60k to 80k miles: 76 complaints 80k to 100k miles: 65 complaints 100k to 120k miles: 60 complaints 120k to 140k miles: 46 complaints 140k to 160k miles: 34 complaints 160k to 180k miles: 21 complaints 180k to 200k miles: 7 complaints 200k+ miles: 3 complaints 040k80k120k160k200k miles Typical: 91,000 miles
Based on 403 complaints that include mileage. 23% were reported before 60,000 miles. The amber marker shows the median: half of these complaints happened before that mileage.
View the numbers
MileageComplaints
0k to 20k miles17
20k to 40k miles25
40k to 60k miles49
60k to 80k miles76
80k to 100k miles65
100k to 120k miles60
120k to 140k miles46
140k to 160k miles34
160k to 180k miles21
180k to 200k miles7
200k+ miles3

What the data shows

Among the 403 complaints that report mileage, the typical (median) problem appeared at about 91,000 miles. For fuel system specifically, the median reported mileage is about 89,000 miles (193 complaints with mileage).

Safety-related details: 20 complaints mention a crash; 13 complaints mention a fire; 36 injuries reported; 3 deaths reported.

Looking only at complaints filed within five years of the model year (so older and newer years are comparable), the 2006 ranks 2nd most-complained-about out of 11 model years of the Mercedes-Benz E350 with enough data (108 complaints in that window). It is also covered by 4 safety recall campaigns.

What owners wrote

A few complaints as filed, shortened and with personal details removed. The first ones are among the most serious reports for this model year; the rest are typical.

I am reporting a very serious, disturbing, shocking and tragic accident on 9/12/2015 on randall road in elgin, il USA at 2:35 pm just after big timber road signal.my southbound 2006 mercedes benz e350 car was hit by the high speed out of control northbound 2014 toyota corolla, which had crossed/swerved the center line and resulted in a head on collision/crash.....updated 10-27-15

Reported at 117,000 miles, September 2015 CrashInjuryDeath

I was driving on the highway and could hear that the engine didn't sound right, it was revving at a higher RPM than normal. I pulled over to see what was wrong and it continued to do this every time I tried to accelerate. I turned the car off, turned it back on and then only had 3rd. Gear available. Nothing else. I later found out that it's called "limp mode" it wouldn't go faster than 40MPH and nothing else worked, just 3rd. Gear and reverse.

Reported at 78,000 miles, October 2012

Fuel pump leaking fumes (and fuel?). While parked and preparing to come home the fuel pump failed and the car refused to start. It will not be repaired unless it is under the extended warranty. I am trying to learn if it will be covered under a extended warranty.

Reported at 155,600 miles, May 2018

Other model years of the E350

Best and worst years for the Mercedes-Benz E350