2021 Mercedes-Benz GLS 580 4MATIC
The EPA rates the 2021 Mercedes-Benz GLS 580 4MATIC at 18 MPG combined (16 city / 21 highway).
At a glance
- Fuel economy
- 18 MPG combined
Sources: NHTSA complaints, recalls and 5-Star ratings; U.S. EPA
Fuel economy
The EPA rates the 2021 Mercedes-Benz GLS 580 4MATIC at 18 MPG combined (16 city / 21 highway).