2025 Mercedes-Benz GLS 580 4MATIC
The EPA rates the 2025 Mercedes-Benz GLS 580 4MATIC at 16 MPG combined (14 city / 19 highway).
At a glance
- Fuel economy
- 16 MPG combined
Sources: NHTSA complaints, recalls and 5-Star ratings; U.S. EPA
Fuel economy
The EPA rates the 2025 Mercedes-Benz GLS 580 4MATIC at 16 MPG combined (14 city / 19 highway).