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2021 Toyota Sienna Hybrid fuel economy

The EPA lists 2 versions of the 2021 Toyota Sienna Hybrid. Combined fuel economy ranges from 35 to 36 MPG; the most efficient version is rated 36 city / 36 highway.

At a glance

Combined
35 to 36 MPG depending on version
City and highway
36 and 36 most efficient version
Yearly fuel cost
$1,850 EPA estimate, most efficient version

Source: U.S. EPA fueleconomy.gov

Every version the EPA tested

VersionEngineDriveCityHighwayCombinedYearly fuel cost
Sienna Hybrid 2WD
Automatic (AV-S6)
4-cyl 2.5L Hybrid Front-Wheel Drive 363636 MPG $1,850
Sienna Hybrid AWD
Automatic (AV-S6)
4-cyl 2.5L Hybrid All-Wheel Drive 353635 MPG $1,900
EPA estimates under standard test conditions. Your mileage will vary with driving style, load and weather.

At EPA assumptions, the most efficient version costs about $1,850 per year in fuel, versus $1,900 for the least efficient.

Work out what this car would cost you in fuel each year

Fuel economy in other model years

  • 2026
  • 2025
  • 2024
  • 2023
  • 2022
  • 2021