2010 Mercedes-Benz E 350 4MATIC
The EPA rates the 2010 Mercedes-Benz E 350 4MATIC at 19 MPG combined (17 city / 24 highway).
At a glance
- Fuel economy
- 19 MPG combined
Sources: NHTSA complaints, recalls and 5-Star ratings; U.S. EPA
Fuel economy
The EPA rates the 2010 Mercedes-Benz E 350 4MATIC at 19 MPG combined (17 city / 24 highway).