Vehicle Data Hub

2021 GMC Sierra 2500 problems

The 2021 GMC Sierra 2500 has 66 complaints on file with NHTSA. The largest share (20%) concerns drivetrain & axles. Next are lighting (14%) and engine (12%).

At a glance

Complaints
66 filed with NHTSA
Most reported
Drivetrain & axles 20% of complaints
Crashes and fires
6 and 3
Injuries and deaths
1 and 0
Typical mileage
52,000 miles 18 complaints with mileage

Source: NHTSA owner complaints

Where the complaints are

Share of this model year's complaints by the part of the car involved. One complaint can name more than one part, so the shares can add up to more than 100%.

  • Drivetrain & axles 20%
  • Lighting 14%
  • Engine 12%
  • Brakes 11%
  • Electrical system 9%
  • Body & structure 8%
  • Latches & locks 6%
  • Forward collision avoidance 5%
  • Air bags 3%
  • Fuel system 3%

When problems show up

Complaints by mileage, 2021 GMC Sierra 2500 Complaints by odometer reading in 20,000-mile steps. The median is about 52,000 miles. 0k to 20k miles: 4 complaints 20k to 40k miles: 1 complaints 40k to 60k miles: 7 complaints 60k to 80k miles: 2 complaints 80k to 100k miles: 1 complaints 100k to 120k miles: 0 complaints 120k to 140k miles: 3 complaints 140k to 160k miles: 0 complaints 160k to 180k miles: 0 complaints 180k to 200k miles: 0 complaints 200k+ miles: 0 complaints 040k80k120k160k200k miles Typical: 52,000 miles
Based on 18 complaints that include mileage. 67% were reported before 60,000 miles. The amber marker shows the median: half of these complaints happened before that mileage.
View the numbers
MileageComplaints
0k to 20k miles4
20k to 40k miles1
40k to 60k miles7
60k to 80k miles2
80k to 100k miles1
100k to 120k miles0
120k to 140k miles3
140k to 160k miles0
160k to 180k miles0
180k to 200k miles0
200k+ miles0

What the data shows

Of the 18 complaints that include odometer readings, half describe a problem before roughly 52,000 miles.

Safety-related details: 6 complaints mention a crash; 3 complaints mention a fire; 1 injury reported.

Looking only at complaints filed within five years of the model year (so older and newer years are comparable), the 2021 ranks 7th most-complained-about out of 26 model years of the GMC Sierra 2500 with enough data (66 complaints in that window). It is also covered by 6 safety recall campaigns.

What owners wrote

A few complaints as filed, shortened and with personal details removed. The first ones are among the most serious reports for this model year; the rest are typical.

The contact owns a 2021 GMC Sierra 2500. The contact stated that while driving at 50 MPH, the contact was pulling a trailer that he had loaded, and he drove around a curve, the gear shifted down independently, and the trailer pushed the vehicle off the right side, causing him to crash into a post and embankment. The contact mentioned he was able to shift the gear into Four Wheel Drive to get back on the road.

Reported at 78,000 miles, October 2025 CrashInjury

I purchased a 2021 GMC Denali 2500 in December 2023. A couple days after purchasing the vehicle I received a message on the dash saying the front camera was not working. I took the vehicle into the dealership where they said they reset the computer and nothing was wrong with the vehicle. One month later I was involved in a collision where a vehicle turned in front of my vehicle and the Automatic Emergency Braking failed to activate.

January 2024 Crash

When I’m in reverse the up the cameras turn off. On one incident I was backing up and the camera turned off causing me to back up into the wall of my house

January 2025 Crash

The contact owns a 2021 GMC Sierra 2500. The contact received Manufacturer's Recall Number: N232426400, for water intrusion into the electronic gate-release switch. The vehicle was repaired. The contact stated that six months after the vehicle was repaired, the tailgate failed to operate as intended. While at the residence, the taillights and headlights were flashing. The contact also became aware that the tailgate had unlatched independently while the vehicle was parked.

Reported at 53,000 miles, July 2025

The contact owns a 2021 GMC Sierra 2500. The contact stated that on several occasions, the automatic power side-out step failed to extend as designed. The vehicle was not diagnosed or repaired. The manufacturer was notified of the failure. The failure mileage was 93,726.

Reported at 93,726 miles, April 2026

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